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Bevantolol hydrochloride

CAS No. 42864-78-8

Bevantolol hydrochloride( NC-1400 hydrochloride )

Catalog No. M21186 CAS No. 42864-78-8

Bevantolol hydrochloride is a β1-adrenoceptor?antagonist that treatment angina pectoris and?hypertension.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Bevantolol hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Bevantolol hydrochloride is a β1-adrenoceptor?antagonist that treatment angina pectoris and?hypertension.
  • Description
    Bevantolol hydrochloride is a β1-adrenoceptor?antagonist that treatment angina pectoris and?hypertension.(In Vitro):Bevantolol hydrochloride has a pKi of 6.23 for β2-adrenergic receptor.(In Vivo):Bevantolol hydrochloride (200 mg/kg; PO by water; for 6 weeks) produces a significant decrease in the expression level of β1 adrenoceptor mRNA.
  • In Vitro
    Bevantolol hydrochloride has a pKi of 6.23 for β2-adrenergic receptor.
  • In Vivo
    Bevantolol hydrochloride (200 mg/kg; PO by water; for 6 weeks) produces a significant decrease in the expression level of β1 adrenoceptor mRNA. Animal Model:Male Wistar rats weighing 250-300 g Dosage:200 mg/kg Administration:PO by water; for 6 weeks Result:Produced a significant decrease in the expression level of β1 adrenoceptor mRNA.
  • Synonyms
    NC-1400 hydrochloride
  • Pathway
    Angiogenesis
  • Target
    Adrenergic Receptor
  • Recptor
    β1-adrenoceptor
  • Research Area
    Cardiovascular Disease
  • Indication
    Essential hypertension

Chemical Information

  • CAS Number
    42864-78-8
  • Formula Weight
    381.9
  • Molecular Formula
    C20H28ClNO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:76 mg/mL (199.01 mM)Ethanol:61 mg/mL (159.73 mM)H2O:52 mg/mL (136.16 mM)
  • SMILES
    COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Noshiro T Miura Y Yoshinaga K et al. Clinical evaluation of bevantolol hydrochloride in patients with severe hypertension. The Cooperative Study Group on Bevantolol in Japan[J]. International Journal of Clinical Pharmacology & Therapeutics 1995 33(4):240-245.
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